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-Structure paper
タイトル | Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2. |
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ジャーナル・号・ページ | Nat Commun, Vol. 12, Issue 1, Page 837, Year 2021 |
掲載日 | 2021年2月5日 |
著者 | Antoni G Wrobel / Donald J Benton / Pengqi Xu / Lesley J Calder / Annabel Borg / Chloë Roustan / Stephen R Martin / Peter B Rosenthal / John J Skehel / Steven J Gamblin / |
PubMed 要旨 | Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind ...Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts a fully-closed conformation and that, aside from the Receptor-Binding Domain, it resembles the spike of a bat coronavirus RaTG13 more than that of SARS-CoV-2. |
リンク | Nat Commun / PubMed:33547281 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 2.9 Å |
構造データ | EMDB-12130, PDB-7bbh: |
化合物 | ChemComp-NAG: |
由来 |
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キーワード | VIRAL PROTEIN / Coronavirus / Pangolin / Spike / Smuggled / DSP |