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-Structure paper
Title | Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis. |
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Journal, issue, pages | J. Org. Chem., Vol. 86, Page 3377-3421, Year 2021 |
Publish date | Feb 21, 2020 (structure data deposition date) |
Authors | Nicolaou, K.C. / Pan, S. / Pulukuri, K.K. / Ye, Q. / Rigol, S. / Erande, R.D. / Vourloumis, D. / Nocek, B.P. / Munneke, S. / Lyssikatos, J. ...Nicolaou, K.C. / Pan, S. / Pulukuri, K.K. / Ye, Q. / Rigol, S. / Erande, R.D. / Vourloumis, D. / Nocek, B.P. / Munneke, S. / Lyssikatos, J. / Valdiosera, A. / Gu, C. / Lin, B. / Sarvaiaya, H. / Trinidad, J. / Sandoval, J. / Lee, C. / Hammond, M. / Aujay, M. / Taylor, N. / Pysz, M. / Purcell, J.W. / Gavrilyuk, J. |
External links | J. Org. Chem. / PubMed:33544599 |
Methods | X-ray diffraction |
Resolution | 2.852 - 3.34 Å |
Structure data | PDB-6y4m: PDB-6y4n: |
Chemicals | ChemComp-GTP: ChemComp-MG: ChemComp-CA: ChemComp-GDP: ChemComp-MES: ChemComp-O9B: ChemComp-O9H: ChemComp-OH5: ChemComp-PGE: ChemComp-VAL: ChemComp-ACP: ChemComp-HOH: ChemComp-O9K: ChemComp-O9N: ChemComp-P6S: ChemComp-PEG: |
Source |
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Keywords | LIGASE / TTL / Tubulin / complex |