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Structure paper

TitleStructural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate.
Journal, issue, pagesIscience, Vol. 24, Page 102036-102036, Year 2021
Publish dateMar 11, 2020 (structure data deposition date)
AuthorsOta, T. / Senoo, A. / Shirakawa, M. / Nonaka, H. / Saito, Y. / Ito, S. / Ueno, G. / Nagatoishi, S. / Tsumoto, K. / Sando, S.
External linksIscience / PubMed:33521601
MethodsX-ray diffraction
Resolution2.30000663987 - 3.1 Å
Structure data

PDB-6m5o:
Co-crystal structure of human serine hydroxymethyltransferase 2 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid
Method: X-RAY DIFFRACTION / Resolution: 2.30000663987 Å

PDB-6m5w:
Co-crystal structure of human serine hydroxymethyltransferase 1 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-DXC:
(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID / detergent*YM

ChemComp-GLY:
GLYCINE

ChemComp-HOH:
WATER

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Inhibitor / Complex

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