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-Structure paper
Title | Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. |
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Journal, issue, pages | Nucleic Acids Res., Vol. 49, Page 2266-2288, Year 2021 |
Publish date | Sep 4, 2020 (structure data deposition date) |
Authors | Ogden, T.E.H. / Yang, J.C. / Schimpl, M. / Easton, L.E. / Underwood, E. / Rawlins, P.B. / McCauley, M.M. / Langelier, M.F. / Pascal, J.M. / Embrey, K.J. / Neuhaus, D. |
External links | Nucleic Acids Res. / PubMed:33511412 |
Methods | X-ray diffraction |
Resolution | 1.593 - 2.8 Å |
Structure data | PDB-7aaa: PDB-7aab: PDB-7aac: PDB-7aad: |
Chemicals | ChemComp-SO4: ChemComp-DMS: ChemComp-EDO: ChemComp-HOH: ChemComp-UHB: ChemComp-78P: ChemComp-09L: |
Source |
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Keywords | TRANSFERASE / PARP / PARylation / PARP inhibitor / substrate mimetic / inhibitor / NADH analog / EB47 / synthetic lethal |