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-Structure paper
Title | Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 33, Page 116019-116019, Year 2021 |
Publish date | Nov 16, 2020 (structure data deposition date) |
Authors | Kuriwaki, I. / Kameda, M. / Iikubo, K. / Hisamichi, H. / Kawamoto, Y. / Kikuchi, S. / Moritomo, H. / Kondoh, Y. / Terasaka, T. / Amano, Y. ...Kuriwaki, I. / Kameda, M. / Iikubo, K. / Hisamichi, H. / Kawamoto, Y. / Kikuchi, S. / Moritomo, H. / Kondoh, Y. / Terasaka, T. / Amano, Y. / Tateishi, Y. / Echizen, Y. / Iwai, Y. / Noda, A. / Tomiyama, H. / Nakazawa, T. / Hirano, M. |
External links | Bioorg. Med. Chem. / PubMed:33486159 |
Methods | X-ray diffraction |
Resolution | 2.57 Å |
Structure data | PDB-7dhl: |
Chemicals | ChemComp-H6X: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / protein kinase / SIGNALING PROTEIN |