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TitleHigh-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.
Journal, issue, pagesNat Commun, Vol. 12, Page 482-482, Year 2021
Publish dateNov 18, 2020 (structure data deposition date)
AuthorsWilliams, J.S. / Tumbale, P.P. / Arana, M.E. / Rana, J.A. / Williams, R.S. / Kunkel, T.A.
External linksNat Commun / PubMed:33473124
MethodsX-ray diffraction
Resolution2.2 - 2.778 Å
Structure data

PDB-7kr3:
Human DNA Ligase 1(E346A/E592A) Bound to a bulged DNA substrate
Method: X-RAY DIFFRACTION / Resolution: 2.778 Å

PDB-7kr4:
Human DNA Ligase 1(E346A/E592A) Bound to a nicked DNA substrate control duplex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsLIGASE/DNA / DNA ligase / DNA replication / DNA repair / Replication / fidelity / LIGASE / LIGASE-DNA complex / Replication fidelity

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