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TitleCrystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism.
Journal, issue, pagesNat Commun, Vol. 12, Page 449-449, Year 2021
Publish dateMay 28, 2020 (structure data deposition date)
AuthorsHan, Y. / Zhuang, Q. / Sun, B. / Lv, W. / Wang, S. / Xiao, Q. / Pang, B. / Zhou, Y. / Wang, F. / Chi, P. ...Han, Y. / Zhuang, Q. / Sun, B. / Lv, W. / Wang, S. / Xiao, Q. / Pang, B. / Zhou, Y. / Wang, F. / Chi, P. / Wang, Q. / Li, Z. / Zhu, L. / Li, F. / Deng, D. / Chiang, Y.C. / Ren, R.
External linksNat Commun / PubMed:33469028
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-7c83:
Crystal structure of an integral membrane steroid 5-alpha-reductase PbSRD5A
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-OLC:
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate

ChemComp-HOH:
WATER

Source
  • proteobacteria bacterium (bacteria)
KeywordsOXIDOREDUCTASE / steroid reductase / NADPH / steroid 3-oxo-delta(4) reduction

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