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-Structure paper
Title | Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. |
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Journal, issue, pages | Nat. Chem. Biol., Vol. 17, Page 412-420, Year 2021 |
Publish date | Jun 19, 2020 (structure data deposition date) |
Authors | Svetlov, M.S. / Syroegin, E.A. / Aleksandrova, E.V. / Atkinson, G.C. / Gregory, S.T. / Mankin, A.S. / Polikanov, Y.S. |
External links | Nat. Chem. Biol. / PubMed:33462493 |
Methods | X-ray diffraction |
Resolution | 2.4 - 2.6 Å |
Structure data | PDB-6xhv: PDB-6xhw: PDB-6xhx: PDB-6xhy: |
Chemicals | ChemComp-MG: ChemComp-K: ChemComp-ZN: ChemComp-SF4: ChemComp-HOH: ChemComp-ERY: ChemComp-MPD: ChemComp-ARG: ChemComp-TEL: |
Source |
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Keywords | RIBOSOME / Macrolide; antibiotic; resistance; methylation; A2058; 23S rRNA; 70S ribosome; X-ray structure; inhibition of translation; peptidyl transferase center; nascent peptide exit tunnel / Macrolide / antibiotic / resistance / methylation / A2058 / 23S rRNA / 70S ribosome / inhibition of translation / peptidyl transferase center / nascent peptide exit tunnel |