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TitleStructure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing.
Journal, issue, pagesNat Commun, Vol. 12, Page 428-428, Year 2021
Publish dateSep 21, 2018 (structure data deposition date)
AuthorsClery, A. / Krepl, M. / Nguyen, C.K.X. / Moursy, A. / Jorjani, H. / Katsantoni, M. / Okoniewski, M. / Mittal, N. / Zavolan, M. / Sponer, J. / Allain, F.H.
External linksNat Commun / PubMed:33462199
MethodsNMR (solution)
Structure data

PDB-6hpj:
Structure of human SRSF1 RRM1 bound to AACAAA RNA
Method: SOLUTION NMR

Source
  • streptococcus sp. group g (bacteria)
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / splicing / SR protein / SRSF1 / RRM / spinal muscular atrophy / SMA / RNA

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