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TitleDiscriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
Journal, issue, pagesJ. Mol. Biol., Vol. 433, Page 166795-166795, Year 2021
Publish dateAug 2, 2019 (structure data deposition date)
AuthorsSalamina, M. / Montefiore, B.C. / Liu, M. / Wood, D.J. / Heath, R. / Ault, J.R. / Wang, L.Z. / Korolchuk, S. / Basle, A. / Pastok, M.W. ...Salamina, M. / Montefiore, B.C. / Liu, M. / Wood, D.J. / Heath, R. / Ault, J.R. / Wang, L.Z. / Korolchuk, S. / Basle, A. / Pastok, M.W. / Reeks, J. / Tatum, N.J. / Sobott, F. / Arold, S.T. / Pagano, M. / Noble, M.E.M. / Endicott, J.A.
External linksJ. Mol. Biol. / PubMed:33422522
MethodsX-ray diffraction
Resolution2.43 Å
Structure data

PDB-6sg4:
Structure of CDK2/cyclin A M246Q, S247EN
Method: X-RAY DIFFRACTION / Resolution: 2.43 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / cyclin-dependent kinases / cancer / cyclin a / cdk2 / skp2

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