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TitleInhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B.
Journal, issue, pagesJ Immunol., Vol. 206, Page 861-873, Year 2021
Publish dateAug 18, 2020 (structure data deposition date)
AuthorsXu, X. / Zhang, C. / Denton, D.T. / O'Connell, D. / Drolet, D.W. / Geisbrecht, B.V.
External linksJ Immunol. / PubMed:33419768
MethodsX-ray diffraction
Resolution3.1 - 3.5 Å
Structure data

PDB-7jtn:
Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 29 Bases
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-7jtq:
Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 31 Bases
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM/DNA / Complement / Protease / Convertase / Inhibitor / Aptamer / IMMUNE SYSTEM / IMMUNE SYSTEM-DNA complex

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