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Structure paper

TitleStructural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.
Journal, issue, pagesScience, Vol. 371, Page 194-200, Year 2021
Publish dateApr 2, 2020 (structure data deposition date)
AuthorsBiering, S.B. / Akey, D.L. / Wong, M.P. / Brown, W.C. / Lo, N.T.N. / Puerta-Guardo, H. / Tramontini Gomes de Sousa, F. / Wang, C. / Konwerski, J.R. / Espinosa, D.A. ...Biering, S.B. / Akey, D.L. / Wong, M.P. / Brown, W.C. / Lo, N.T.N. / Puerta-Guardo, H. / Tramontini Gomes de Sousa, F. / Wang, C. / Konwerski, J.R. / Espinosa, D.A. / Bockhaus, N.J. / Glasner, D.R. / Li, J. / Blanc, S.F. / Juan, E.Y. / Elledge, S.J. / Mina, M.J. / Beatty, P.R. / Smith, J.L. / Harris, E.
External linksScience / PubMed:33414220
MethodsX-ray diffraction
Resolution2.89 - 3.96 Å
Structure data

PDB-6weq:
DENV1 NS1 in complex with neutralizing 2B7 Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-6wer:
DENV2 NS1 in complex with neutralizing 2B7 Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 3.96 Å

PDB-7k93:
DENV2 NS1 in complex with neutralizing 2B7 single chain Fab variable region (scFv)
Method: X-RAY DIFFRACTION / Resolution: 2.89 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

Source
  • dengue virus 1
  • mus musculus (house mouse)
  • dengue virus 2
KeywordsVIRAL PROTEIN / Flavivirus NS1 / Antibody / Fab fragment

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