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TitleA broadly protective antibody that targets the flavivirus NS1 protein.
Journal, issue, pagesScience, Vol. 371, Page 190-194, Year 2021
Publish dateMar 30, 2020 (structure data deposition date)
AuthorsModhiran, N. / Song, H. / Liu, L. / Bletchly, C. / Brillault, L. / Amarilla, A.A. / Xu, X. / Qi, J. / Chai, Y. / Cheung, S.T.M. ...Modhiran, N. / Song, H. / Liu, L. / Bletchly, C. / Brillault, L. / Amarilla, A.A. / Xu, X. / Qi, J. / Chai, Y. / Cheung, S.T.M. / Traves, R. / Setoh, Y.X. / Bibby, S. / Scott, C.A.P. / Freney, M.E. / Newton, N.D. / Khromykh, A.A. / Chappell, K.J. / Muller, D.A. / Stacey, K.J. / Landsberg, M.J. / Shi, Y. / Gao, G.F. / Young, P.R. / Watterson, D.
External linksScience / PubMed:33414219
MethodsX-ray diffraction
Resolution2.31 - 2.53 Å
Structure data

PDB-7bsc:
Complex structure of 1G5.3 Fab bound to DENV2 NS1c
Method: X-RAY DIFFRACTION / Resolution: 2.31 Å

PDB-7bsd:
Complex structure of 1G5.3 Fab bound to ZIKV NS1c
Method: X-RAY DIFFRACTION / Resolution: 2.53 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • dengue virus 2
  • homo sapiens (human)
  • zika virus
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Dengue virus / NS1 / antibody / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complex / IMMUNE SYSTEM/VIRAL PROTEIN / Zika virus / IMMUNE SYSTEM-VIRAL PROTEIN complex

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