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Structure paper

TitleFunctional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A.
Journal, issue, pagesCell Chem Biol, Vol. 28, Page 825-, Year 2021
Publish dateJun 26, 2020 (structure data deposition date)
AuthorsNaineni, S.K. / Liang, J. / Hull, K. / Cencic, R. / Zhu, M. / Northcote, P. / Teesdale-Spittle, P. / Romo, D. / Nagar, B. / Pelletier, J.
External linksCell Chem Biol / PubMed:33412110
MethodsX-ray diffraction
Resolution2.87 Å
Structure data

PDB-6xki:
Crystal structure of eIF4A-I in complex with RNA bound to des-MePateA, a pateamine A analog
Method: X-RAY DIFFRACTION / Resolution: 2.87 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-V6D:
(3S,6Z,8E,11S,15R)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11-dimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • synthetic construct (others)
KeywordsTRANSLATION/RNA/INHIBITOR / Inhibitor / RNA / Translation initiation / TRANSLATION / TRANSLATION-RNA-INHIBITOR complex

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