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-Structure paper
Title | Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension. |
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Journal, issue, pages | Acta Pharm Sin B, Vol. 10, Page 2339-2347, Year 2020 |
Publish date | Mar 22, 2020 (structure data deposition date) |
Authors | Yang, Y. / Zhang, S. / Zhou, Q. / Zhang, C. / Gao, Y. / Wang, H. / Li, Z. / Wu, D. / Wu, Y. / Huang, Y.Y. ...Yang, Y. / Zhang, S. / Zhou, Q. / Zhang, C. / Gao, Y. / Wang, H. / Li, Z. / Wu, D. / Wu, Y. / Huang, Y.Y. / Guo, L. / Luo, H.B. |
External links | Acta Pharm Sin B / PubMed:33354505 |
Methods | X-ray diffraction |
Resolution | 2.40008632403 Å |
Structure data | PDB-7bpi: |
Chemicals | ChemComp-ZN: ChemComp-MG: ChemComp-DZU: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / PDE10A inhibitor |