タイトル | Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands. |
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ジャーナル・号・ページ | Acs Med. Chem. Lett., Vol. 11, Page 2484-2490, Year 2020 |
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掲載日 | 2020年5月25日 (構造データの登録日) |
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著者 | Niggenaber, J. / Heyden, L. / Grabe, T. / Muller, M.P. / Lategahn, J. / Rauh, D. |
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リンク | Acs Med. Chem. Lett. / PubMed:33335671 |
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手法 | X線回折 |
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解像度 | 1.9 - 2.5 Å |
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構造データ | PDB-6z4b: Crystal Structure of EGFR-T790M/V948R in Complex with Osimertinib and EAI045 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-6z4d: Crystal Structure of EGFR-T790M/V948R in Complex with Mavelertinib and EAI001 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-7a2a: Crystal Structure of EGFR-T790M/V948R in Complex with Spebrutinib and EAI001 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å |
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化合物 | ChemComp-Q6K: ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide
ChemComp-9LL: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide
ChemComp-8BS: N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide
ChemComp-57N: (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide
ChemComp-7G9: ~{N}-[3-[[5-fluoranyl-2-[[4-(2-methoxyethoxy)phenyl]amino]pyrimidin-4-yl]amino]phenyl]propanamide
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / EGFR |
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