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TitlePre-T cell receptors topologically sample self-ligands during thymocyte beta-selection.
Journal, issue, pagesScience, Vol. 371, Page 181-185, Year 2021
Publish dateApr 18, 2020 (structure data deposition date)
AuthorsLi, X. / Mizsei, R. / Tan, K. / Mallis, R.J. / Duke-Cohan, J.S. / Akitsu, A. / Tetteh, P.W. / Dubey, A. / Hwang, W. / Wagner, G. ...Li, X. / Mizsei, R. / Tan, K. / Mallis, R.J. / Duke-Cohan, J.S. / Akitsu, A. / Tetteh, P.W. / Dubey, A. / Hwang, W. / Wagner, G. / Lang, M.J. / Arthanari, H. / Wang, J.H. / Reinherz, E.L.
External linksScience / PubMed:33335016
MethodsX-ray diffraction
Resolution1.95 - 3.6 Å
Structure data

PDB-6wl2:
preTCRbeta-pMHC complex crystal structure
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-6wl3:
preTCRbeta-pMHC complex crystal structure
Method: X-RAY DIFFRACTION / Resolution: 3.45 Å

PDB-6wl4:
preTCRbeta-pMHC complex crystal structure
Method: X-RAY DIFFRACTION / Resolution: 3.6 Å

PDB-7ji2:
Crystal Structure of H2-Kb in complex with a OVA mutant peptide
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • vesicular stomatitis virus
  • mus musculus bactrianus (southwestern Asian house mouse)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / preTCR / H-2Kb / T cell development / beta selection / H2-Kb

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