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TitleDiscovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity.
Journal, issue, pagesJ. Pharmacol. Exp. Ther., Vol. 376, Page 397-409, Year 2021
Publish dateJun 29, 2020 (structure data deposition date)
AuthorsVlach, J. / Bender, A.T. / Przetak, M. / Pereira, A. / Deshpande, A. / Johnson, T.L. / Reissig, S. / Tzvetkov, E. / Musil, D. / Morse, N.T. ...Vlach, J. / Bender, A.T. / Przetak, M. / Pereira, A. / Deshpande, A. / Johnson, T.L. / Reissig, S. / Tzvetkov, E. / Musil, D. / Morse, N.T. / Haselmayer, P. / Zimmerli, S.C. / Okitsu, S.L. / Walsky, R.L. / Sherer, B.
External linksJ. Pharmacol. Exp. Ther. / PubMed:33328334
MethodsX-ray diffraction
Resolution2.489 Å
Structure data

PDB-6zjz:
Discovery of M5049: a novel selective TLR7/8 inhibitor for treatment of autoimmunity
Method: X-RAY DIFFRACTION / Resolution: 2.489 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-QLH:
5-[(3~{R},5~{S})-3-azanyl-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / LEUCINE RICH REPEAT / RNA / GLYCOSYLATION / INNATE IMMUNITY

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