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TitleSubstrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8.
Journal, issue, pagesCommun Biol, Vol. 3, Page 752-752, Year 2020
Publish dateJan 6, 2020 (structure data deposition date)
AuthorsYe, Y. / Xiong, Y. / Huang, H.
External linksCommun Biol / PubMed:33303953
MethodsX-ray diffraction
Resolution2.75 - 3.72 Å
Structure data

PDB-6loj:
The complex structure of IpaH9.8-LRR and hGBP1
Method: X-RAY DIFFRACTION / Resolution: 3.72 Å

PDB-6lol:
The crystal structure of full length IpaH9.8
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

Source
  • shigella flexneri (bacteria)
  • homo sapiens (human)
  • shigella flexneri 2002017 (bacteria)
KeywordsLIGASE/HYDROLASE / IpaH9.8 / hGBP1 / LRR / TRANSFERASE / LIGASE-HYDROLASE complex / E3

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