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TitleDiscovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development.
Journal, issue, pagesJ. Med. Chem., Vol. 63, Page 15541-15563, Year 2020
Publish dateJul 29, 2020 (structure data deposition date)
AuthorsWang, H. / Ren, B. / Liu, Y. / Jiang, B. / Guo, Y. / Wei, M. / Luo, L. / Kuang, X. / Qiu, M. / Lv, L. ...Wang, H. / Ren, B. / Liu, Y. / Jiang, B. / Guo, Y. / Wei, M. / Luo, L. / Kuang, X. / Qiu, M. / Lv, L. / Xu, H. / Qi, R. / Yan, H. / Xu, D. / Wang, Z. / Huo, C.X. / Zhu, Y. / Zhao, Y. / Wu, Y. / Qin, Z. / Su, D. / Tang, T. / Wang, F. / Sun, X. / Feng, Y. / Peng, H. / Wang, X. / Gao, Y. / Gong, W. / Yu, F. / Liu, X. / Wang, L. / Zhou, C.
External linksJ. Med. Chem. / PubMed:33264017
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-7cmw:
Complex structure of PARP1 catalytic domain with pamiparib
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-DS9:
(2R)-14-fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN / PARP1 / pamiparib / BGB-290 / transferase

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