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Structure paper

TitleModulation of Amyloidogenic Protein Self-Assembly Using Tethered Small Molecules.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 142, Page 20845-20854, Year 2020
Publish dateSep 20, 2020 (structure data deposition date)
AuthorsCawood, E.E. / Guthertz, N. / Ebo, J.S. / Karamanos, T.K. / Radford, S.E. / Wilson, A.J.
External linksJ. Am. Chem. Soc. / PubMed:33253560
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-7afv:
Crystal structure of tetrameric beta-2-microglobulin deltaN6 S52C stabilized by a covalent ligand
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-SJK:
5-oxidanylidene-~{N}-(2-sulfanylethyl)-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / beta-2-microglobulin / tetramer / covalent inhibitor

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