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-Structure paper
Title | Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP). |
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Journal, issue, pages | Biochim Biophys Acta Gen Subj, Vol. 1865, Page 129800-129800, Year 2020 |
Publish date | Jan 7, 2020 (structure data deposition date) |
Authors | Ho, J.D. / Lee, M.R. / Rauch, C.T. / Aznavour, K. / Park, J.S. / Luz, J.G. / Antonysamy, S. / Condon, B. / Maletic, M. / Zhang, A. ...Ho, J.D. / Lee, M.R. / Rauch, C.T. / Aznavour, K. / Park, J.S. / Luz, J.G. / Antonysamy, S. / Condon, B. / Maletic, M. / Zhang, A. / Hickey, M.J. / Hughes, N.E. / Chandrasekhar, S. / Sloan, A.V. / Gooding, K. / Harvey, A. / Yu, X.P. / Kahl, S.D. / Norman, B.H. |
External links | Biochim Biophys Acta Gen Subj / PubMed:33246032 |
Methods | X-ray diffraction |
Resolution | 1.4 - 2.61 Å |
Structure data | PDB-6vgc: PDB-6vgi: PDB-6vl4: |
Chemicals | ChemComp-QY1: ChemComp-CA: ChemComp-BOG: ChemComp-HOH: ChemComp-QY7: ChemComp-SO4: ChemComp-PG4: |
Source |
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Keywords | MEMBRANE PROTEIN / 5-Lipoxygenase Activating Protein / FLAP / DG-031 / MK-866 / ISOMERASE / mPGES-1 |