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Structure paper

TitleDiscovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody.
Journal, issue, pagesMabs, Vol. 12, Page 1831880-1831880
Publish dateMay 14, 2020 (structure data deposition date)
AuthorsBoyles, J.S. / Beidler, C.B. / Strifler, B.A. / Girard, D.S. / Druzina, Z. / Durbin, J.D. / Swearingen, M.L. / Lee, L.N. / Kikly, K. / Chintharlapalli, S. / Witcher, D.R.
External linksMabs / PubMed:33183151
MethodsX-ray diffraction
Resolution1.8 - 2.37 Å
Structure data

PDB-6wzj:
LY3041658 Fab bound to CXCL2
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

PDB-6wzk:
LY3041658 Fab bound to CXCL3
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6wzl:
LY3041658 Fab bound to CXCL7
Method: X-RAY DIFFRACTION / Resolution: 2.29 Å

PDB-6wzm:
LY3041658 Fab bound to CXCL8
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACT:
ACETATE ION

ChemComp-MG:
Unknown entry

ChemComp-PG6:
1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

Source
  • homo sapiens (human)
  • macaca fascicularis (crab-eating macaque)
KeywordsIMMUNE SYSTEM / CXCR1 / CXCR2 / neutrophil / GRO-beta / GRO-gamma / NAP-2 / interleukin-8

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