Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	5-Phenyl-1,3,4-oxadiazol-2(3 H )-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.
Journal, issue, pages	J. Med. Chem., Vol. 63, Page 12942-12956, Year 2020
Publish date	Jul 23, 2020 (structure data deposition date)
Authors	Mahy, W. / Willis, N.J. / Zhao, Y. / Woodward, H.L. / Svensson, F. / Sipthorp, J. / Vecchia, L. / Ruza, R.R. / Hillier, J. / Kjaer, S. ...Mahy, W. / Willis, N.J. / Zhao, Y. / Woodward, H.L. / Svensson, F. / Sipthorp, J. / Vecchia, L. / Ruza, R.R. / Hillier, J. / Kjaer, S. / Frew, S. / Monaghan, A. / Bictash, M. / Salinas, P.C. / Whiting, P. / Vincent, J.P. / Jones, E.Y. / Fish, P.V.
External links	J. Med. Chem. / PubMed:33124429
Methods	X-ray diffraction
Resolution	1.3 - 1.54 Å
Structure data	PDB-6zuv: Notum fragment 286 Method: X-RAY DIFFRACTION / Resolution: 1.54 Å PDB-6zvl: ARUK3000263 complex with Notum Method: X-RAY DIFFRACTION / Resolution: 1.3 Å
Chemicals	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose ChemComp-SO4: SULFATE ION ChemComp-EDO: 1,2-ETHANEDIOL ChemComp-B1J: [1-(4-chlorophenyl)-1,2,3-triazol-4-yl]methanol ChemComp-HOH: WATER ChemComp-DMS: DIMETHYL SULFOXIDE / DMSO, precipitantYM ChemComp-QR2*: 5-[4-chloranyl-3-(trifluoromethyl)phenyl]-3~{H}-1,3,4-oxadiazol-2-one
Source	homo sapiens (human)
Keywords	SIGNALING PROTEIN / Wnt Notum inhibitor complex / Notum / inhibitor / Wnt