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-Structure paper
Title | A drug-resistant beta-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. |
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Journal, issue, pages | J. Biol. Chem., Vol. 295, Page 18239-18255, Year 2020 |
Publish date | Sep 9, 2020 (structure data deposition date) |
![]() | Soeung, V. / Lu, S. / Hu, L. / Judge, A. / Sankaran, B. / Prasad, B.V.V. / Palzkill, T. |
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Methods | X-ray diffraction |
Resolution | 1.4 - 1.8 Å |
Structure data | ![]() PDB-7k2w: ![]() PDB-7k2x: ![]() PDB-7k2y: |
Chemicals | ![]() ChemComp-CEF: ![]() ChemComp-HOH: ![]() ChemComp-GOL: ![]() ChemComp-AIX: |
Source |
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![]() | HYDROLASE / antibiotic resistance / acyl-enzyme intermediate / CTX-M-14 |