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TitleDomain interactions reveal auto-inhibition of the deubiquitinating enzyme USP19 and its activation by HSP90 in the modulation of huntingtin aggregation.
Journal, issue, pagesBiochem. J., Vol. 477, Page 4295-4312, Year 2020
Publish dateJun 10, 2019 (structure data deposition date)
AuthorsXue, W. / Zhang, S.X. / He, W.T. / Hong, J.Y. / Jiang, L.L. / Hu, H.Y.
External linksBiochem. J. / PubMed:33094816
MethodsNMR (solution)
Structure data

PDB-6k7w:
Solution Structure of the CS1 Domain of USP19
Method: SOLUTION NMR

PDB-6khv:
Solution Structure of the CS2 Domain of USP19
Method: SOLUTION NMR

PDB-6kqv:
Solution Structure of the UbL Domain of USP19
Method: SOLUTION NMR

Source
  • homo sapiens (human)
KeywordsHYDROLASE INHIBITOR / CS domain / Autoinhibitory Regulation / HYDROLASE / HSP90 / UbL domain

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