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-Structure paper
Title | Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. |
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Journal, issue, pages | Mol. Cancer Ther., Vol. 19, Page 2502-2515, Year 2020 |
Publish date | Jan 29, 2020 (structure data deposition date) |
![]() | McDonald, G. / Chubukov, V. / Coco, J. / Truskowski, K. / Narayanaswamy, R. / Choe, S. / Steadman, M. / Artin, E. / Padyana, A.K. / Jin, L. ...McDonald, G. / Chubukov, V. / Coco, J. / Truskowski, K. / Narayanaswamy, R. / Choe, S. / Steadman, M. / Artin, E. / Padyana, A.K. / Jin, L. / Ronseaux, S. / Locuson, C. / Fan, Z.P. / Erdmann, T. / Mann, A. / Hayes, S. / Fletcher, M. / Nellore, K. / Rao, S.S. / Subramanya, H. / Reddy, K.S. / Panigrahi, S.K. / Antony, T. / Gopinath, S. / Sui, Z. / Nagaraja, N. / Dang, L. / Lenz, G. / Hurov, J. / Biller, S.A. / Murtie, J. / Marks, K.M. / Ulanet, D.B. |
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Methods | X-ray diffraction |
Resolution | 1.97 Å |
Structure data | ![]() PDB-6vnd: |
Chemicals | ![]() ChemComp-R4P: ![]() ChemComp-DET: ![]() ChemComp-DDQ: ![]() ChemComp-CL: ![]() ChemComp-NA: ![]() ChemComp-FMN: ![]() ChemComp-ORO: ![]() ChemComp-ACT: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / DHODH / OXIDOREDUCTASE / FMN binding / Inhibitor / Mitochondria inner membrane / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |