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-Structure paper
タイトル | High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex. |
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ジャーナル・号・ページ | Structure, Vol. 29, Issue 1, Page 50-60.e4, Year 2021 |
掲載日 | 2021年1月7日 |
著者 | Cristina Risi / Luisa U Schäfer / Betty Belknap / Ian Pepper / Howard D White / Gunnar F Schröder / Vitold E Galkin / |
PubMed 要旨 | Heart contraction depends on a complicated array of interactions between sarcomeric proteins required to convert chemical energy into mechanical force. Cyclic interactions between actin and myosin ...Heart contraction depends on a complicated array of interactions between sarcomeric proteins required to convert chemical energy into mechanical force. Cyclic interactions between actin and myosin molecules, controlled by troponin and tropomyosin, generate the sliding force between the actin-based thin and myosin-based thick filaments. Alterations in this sophisticated system due to missense mutations can lead to cardiovascular diseases. Numerous structural studies proposed pathological mechanisms of missense mutations at the myosin-myosin, actin-tropomyosin, and tropomyosin-troponin interfaces. However, despite the central role of actomyosin interactions a detailed structural description of the cardiac actomyosin interface remained unknown. Here, we report a cryo-EM structure of a cardiac actomyosin complex at 3.8 Å resolution. The structure reveals the molecular basis of cardiac diseases caused by missense mutations in myosin and actin proteins. |
リンク | Structure / PubMed:33065066 / PubMed Central |
手法 | EM (らせん対称) |
解像度 | 3.8 Å |
構造データ | EMDB-22335, PDB-7jh7: |
化合物 | ChemComp-ADP: ChemComp-MG: |
由来 |
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キーワード | MOTOR PROTEIN / actomyosin |