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Title | Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3 H -isobenzofuran-5-yl)-[1,2,4]triazolo[1,5- a ]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel "Dual-Soft" PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 14502-14521, Year 2020 |
Publish date | Jun 8, 2020 (structure data deposition date) |
Authors | Larsen, J. / Lambert, M. / Pettersson, H. / Vifian, T. / Larsen, M. / Ollerstam, A. / Hegardt, P. / Eskilsson, C. / Laursen, S. / Soehoel, A. ...Larsen, J. / Lambert, M. / Pettersson, H. / Vifian, T. / Larsen, M. / Ollerstam, A. / Hegardt, P. / Eskilsson, C. / Laursen, S. / Soehoel, A. / Skak-Nielsen, T. / Hansen, L.M. / Knudsen, N.O. / Eirefelt, S. / Sorensen, M.D. / Stilou, T.G. / Nielsen, S.F. |
External links | J. Med. Chem. / PubMed:33054196 |
Methods | X-ray diffraction |
Resolution | 1.6 Å |
Structure data | PDB-6zba: |
Chemicals | ChemComp-QDT: ChemComp-EDO: ChemComp-DMS: ChemComp-MG: ChemComp-ZN: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / phosphodiesterase / phosphodiesterase inhibitor |