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Structure paper

TitleStructure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus.
Journal, issue, pagesMbio, Vol. 11, Year 2020
Publish dateFeb 11, 2020 (structure data deposition date)
AuthorsJiang, H. / Peng, W. / Qi, J. / Chai, Y. / Song, H. / Bi, Y. / Rijal, P. / Wang, H. / Oladejo, B.O. / Liu, J. ...Jiang, H. / Peng, W. / Qi, J. / Chai, Y. / Song, H. / Bi, Y. / Rijal, P. / Wang, H. / Oladejo, B.O. / Liu, J. / Shi, Y. / Gao, G.F. / Townsend, A.R. / Wu, Y.
External linksMbio / PubMed:33024040
MethodsX-ray diffraction
Resolution2.5 - 3.608 Å
Structure data

PDB-6lxi:
Crystal structure of Z2B3 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6lxj:
Crystal structure of human Z2B3 Fab in complex with influenza virus neuraminidase from A/Anhui/1/2013 (H7N9)
Method: X-RAY DIFFRACTION / Resolution: 2.903 Å

PDB-6lxk:
Crystal structure of Z2B3 D102R Fab in complex with influenza virus neuraminidase from A/Serbia/NS-601/2014 (H1N1)
Method: X-RAY DIFFRACTION / Resolution: 3.608 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • influenza a virus (strain a/brevig mission/1/1918 h1n1)
  • homo sapiens (human)
  • influenza a virus (a/anhui/1-balf_rg44/2013(h7n9))
  • influenza a virus
KeywordsHYDROLASE/IMMUNE SYSTEM / antibody / antigen / complex / IMMUNE SYSTEM / HYDROLASE-IMMUNE SYSTEM complex

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