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Structure paper

TitleTASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
Journal, issue, pagesNat Commun, Vol. 11, Page 4940-4940, Year 2020
Publish dateNov 29, 2019 (structure data deposition date)
AuthorsDouse, C.H. / Tchasovnikarova, I.A. / Timms, R.T. / Protasio, A.V. / Seczynska, M. / Prigozhin, D.M. / Albecka, A. / Wagstaff, J. / Williamson, J.C. / Freund, S.M.V. ...Douse, C.H. / Tchasovnikarova, I.A. / Timms, R.T. / Protasio, A.V. / Seczynska, M. / Prigozhin, D.M. / Albecka, A. / Wagstaff, J. / Williamson, J.C. / Freund, S.M.V. / Lehner, P.J. / Modis, Y.
External linksNat Commun / PubMed:33009411
MethodsX-ray diffraction
Resolution2.03 Å
Structure data

PDB-6tl1:
Crystal structure of the TASOR pseudo-PARP domain
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / Nuclear protein; Transcriptional repressor; epigenetic silencing; histone H3 lysine 9 methylation (H3K9me3); transposable element; LINE1 element; RNA-binding protein

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