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TitleFormat chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices.
Journal, issue, pagesNat Commun, Vol. 11, Page 4974-4974, Year 2020
Publish dateApr 22, 2020 (structure data deposition date)
AuthorsDengl, S. / Mayer, K. / Bormann, F. / Duerr, H. / Hoffmann, E. / Nussbaum, B. / Tischler, M. / Wagner, M. / Kuglstatter, A. / Leibrock, L. ...Dengl, S. / Mayer, K. / Bormann, F. / Duerr, H. / Hoffmann, E. / Nussbaum, B. / Tischler, M. / Wagner, M. / Kuglstatter, A. / Leibrock, L. / Buldun, C. / Georges, G. / Brinkmann, U.
External linksNat Commun / PubMed:33009381
MethodsX-ray diffraction
Resolution1.55 - 2.05 Å
Structure data

PDB-6ysc:
GLYCOSYLATED KNOB-HOLE/DUMMY FC FRAGMENT
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-6yt7:
GLYCOSYLATED KNOB/DUMMY-HOLE FC FRAGMENT
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-6ytb:
GLYCOSYLATED KNOB/DUMMY-HOLE/DUMMY FC FRAGMENT
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / BISPECIFIC ANTIBODY / FC ENGINEERING / KNOB-INTO-HOLE / FORCE / FORMAT CHAIN EXCHANGE / BISPECIFIC ANTIBODY FC ENGINEERING

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