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-Structure paper
Title | Periphilin self-association underpins epigenetic silencing by the HUSH complex. |
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Journal, issue, pages | Nucleic Acids Res., Vol. 48, Page 10313-10328, Year 2020 |
Publish date | Sep 20, 2019 (structure data deposition date) |
Authors | Prigozhin, D.M. / Douse, C.H. / Farleigh, L.E. / Albecka, A. / Tchasovnikarova, I.A. / Timms, R.T. / Oda, S.I. / Adolf, F. / Freund, S.M.V. / Maslen, S. ...Prigozhin, D.M. / Douse, C.H. / Farleigh, L.E. / Albecka, A. / Tchasovnikarova, I.A. / Timms, R.T. / Oda, S.I. / Adolf, F. / Freund, S.M.V. / Maslen, S. / Lehner, P.J. / Modis, Y. |
External links | Nucleic Acids Res. / PubMed:32976585 |
Methods | X-ray diffraction |
Resolution | 2.51 Å |
Structure data | PDB-6swg: |
Chemicals | ChemComp-SO4: |
Source |
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Keywords | GENE REGULATION / Nuclear protein; Transcriptional repressor; epigenetic silencing; histone H3 lysine 9 methylation (H3K9me3); transposable element; LINE1 element; low-complexity sequence; liquid-liquid phase separation (LLPS); membrane-less compartment; RNA-binding protein |