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TitleIRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex.
Journal, issue, pagesNat Commun, Vol. 11, Page 4775-4775, Year 2020
Publish dateJun 5, 2020 (structure data deposition date)
AuthorsDavila-Calderon, J. / Patwardhan, N.N. / Chiu, L.Y. / Sugarman, A. / Cai, Z. / Penutmutchu, S.R. / Li, M.L. / Brewer, G. / Hargrove, A.E. / Tolbert, B.S.
External linksNat Commun / PubMed:32963221
MethodsNMR (solution)
Structure data

PDB-6xb7:
IRES-targeting Small Molecule Inhibits Enterovirus 71 Replication via Allosteric Stabilization of a Ternary Complex
Method: SOLUTION NMR

Chemicals

ChemComp-UYS:
3-amino-N-(diaminomethylidene)-5-(dimethylamino)-6-(phenylethynyl)pyrazine-2-carboxamide

Source
  • enterovirus a71
KeywordsRNA / RNA-small molecule complex / RNA binding protein

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