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TitleDiscovery of novel liver X receptor inverse agonists as lipogenesis inhibitors.
Journal, issue, pagesEur. J. Med. Chem., Vol. 206, Page 112793-112793, Year 2020
Publish dateJun 16, 2019 (structure data deposition date)
AuthorsChen, Z. / Chen, H. / Zhang, Z. / Ding, P. / Yan, X. / Li, Y. / Zhang, S. / Gu, Q. / Zhou, H. / Xu, J.
External linksEur. J. Med. Chem. / PubMed:32961480
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-6k9m:
Human LXR-beta in complex with an agonist
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-D43:
~{tert}-butyl (2'~{S},3~{S})-2-oxidanylidene-2'-propan-2-yl-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / Nuclear receptor

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