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Structure paper

TitleCH7233163 Overcomes Osimertinib-Resistant EGFR-Del19/T790M/C797S Mutation.
Journal, issue, pagesMol. Cancer Ther., Vol. 19, Page 2288-2297, Year 2020
Publish dateJan 27, 2020 (structure data deposition date)
AuthorsKashima, K. / Kawauchi, H. / Tanimura, H. / Tachibana, Y. / Chiba, T. / Torizawa, T. / Sakamoto, H.
External linksMol. Cancer Ther. / PubMed:32943545
MethodsX-ray diffraction
Resolution2.05 - 2.315 Å
Structure data

PDB-6lub:
Crystal Structure of EGFR(L858R/T790M/C797S) in complex with CH7233163
Method: X-RAY DIFFRACTION / Resolution: 2.315 Å

PDB-6lud:
Crystal Structure of EGFR(L858R/T790M/C797S) in complex with Osimertinib
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-EUX:
N-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-7-(4-methylpiperazin-1-yl)-5-propan-2-yl-9-[2,2,2-tris(fluoranyl)ethoxy]pyrido[4,3-b]indol-3-amine

ChemComp-HOH:
WATER

ChemComp-YY3:
N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide / medication, inhibitor*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / PROTEIN KINASE / INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX / TRANSFERASE

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