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Structure paper

TitleStructure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism.
Journal, issue, pagesMol. Pharmacol., Vol. 98, Page 529-539, Year 2020
Publish dateJan 25, 2020 (structure data deposition date)
AuthorsParikh, S.J. / Evans, C.M. / Obi, J.O. / Zhang, Q. / Maekawa, K. / Glass, K.C. / Shah, M.B.
External linksMol. Pharmacol. / PubMed:32938720
MethodsX-ray diffraction
Resolution3.12 Å
Structure data

PDB-6vlt:
Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Method: X-RAY DIFFRACTION / Resolution: 3.12 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-LSN:
[2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol / medication*YM

ChemComp-CM5:
5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE / detergent*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / CYP2C9*2 / CYP2C9 R144C

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