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TitleMolecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy.
Journal, issue, pagesMol Ther Oncolytics, Vol. 18, Page 443-456, Year 2020
Publish dateDec 5, 2019 (structure data deposition date)
AuthorsCrean, R.M. / MacLachlan, B.J. / Madura, F. / Whalley, T. / Rizkallah, P.J. / Holland, C.J. / McMurran, C. / Harper, S. / Godkin, A. / Sewell, A.K. ...Crean, R.M. / MacLachlan, B.J. / Madura, F. / Whalley, T. / Rizkallah, P.J. / Holland, C.J. / McMurran, C. / Harper, S. / Godkin, A. / Sewell, A.K. / Pudney, C.R. / van der Kamp, M.W. / Cole, D.K.
External linksMol Ther Oncolytics / PubMed:32913893
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-6tmo:
Structure determination of an enhanced affinity TCR, a24b17, in complex with HLA-A*02:01 presenting a MART-1 peptide, EAAGIGILTV
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-TAM:
TRIS(HYDROXYETHYL)AMINOMETHANE / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / High affinity / T-cell receptor

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