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-Structure paper
Title | Covalent inhibition of NSD1 histone methyltransferase. |
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Journal, issue, pages | Nat. Chem. Biol., Vol. 16, Page 1403-1410, Year 2020 |
Publish date | Aug 18, 2019 (structure data deposition date) |
Authors | Huang, H. / Howard, C.A. / Zari, S. / Cho, H.J. / Shukla, S. / Li, H. / Ndoj, J. / Gonzalez-Alonso, P. / Nikolaidis, C. / Abbott, J. ...Huang, H. / Howard, C.A. / Zari, S. / Cho, H.J. / Shukla, S. / Li, H. / Ndoj, J. / Gonzalez-Alonso, P. / Nikolaidis, C. / Abbott, J. / Rogawski, D.S. / Potopnyk, M.A. / Kempinska, K. / Miao, H. / Purohit, T. / Henderson, A. / Mapp, A. / Sulis, M.L. / Ferrando, A. / Grembecka, J. / Cierpicki, T. |
External links | Nat. Chem. Biol. / PubMed:32868895 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.4 Å |
Structure data | PDB-6kqp: PDB-6kqq: |
Chemicals | ChemComp-SAM: ChemComp-ZN: ChemComp-HOH: ChemComp-DQL: ChemComp-DW9: ChemComp-CA: ChemComp-GOL: |
Source |
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Keywords | TRANSFERASE / histone-methyltransferase / SAM complex / SAM / Inhibitor complex |