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TitleConformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 117, Page 22341-22350, Year 2020
Publish dateMay 27, 2019 (structure data deposition date)
AuthorsBurnett, D.L. / Schofield, P. / Langley, D.B. / Jackson, J. / Bourne, K. / Wilson, E. / Porebski, B.T. / Buckle, A.M. / Brink, R. / Goodnow, C.C. / Christ, D.
External linksProc. Natl. Acad. Sci. USA / PubMed:32855302
MethodsX-ray diffraction
Resolution1.05 - 2.2 Å
Structure data

PDB-6p4a:
HyHEL10 Fab complexed with hen egg lysozyme carrying two mutations (HEL2x-rigid): R21Q and R73E
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-6p4b:
HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6p4c:
HyHEL10 Fab carrying four heavy chain mutations (HyHEL10-4x): L4F, Y33H, S56N, and Y58F
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-6p4d:
Hen egg lysozyme (HEL) containing three point mutations (HEL3x): R21Q, R73E, and D101R
Method: X-RAY DIFFRACTION / Resolution: 1.05 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • gallus gallus (chicken)
KeywordsHYDROLASE/IMMUNE SYSTEM / HyHEL10 / HEL2x-rigid / antibody-antigen / HyHEL10-HEL2x / HYDROLASE-IMMUNE SYSTEM complex / HEL2x-flex / HyHEL10-4x / Fab / antigen-antibody / IMMUNE SYSTEM / lysozyme-binder / HYDROLASE / hen egg lysozyme HEL3x

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