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TitlePharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody.
Journal, issue, pagesMol. Cancer Ther., Vol. 19, Page 2105-2116, Year 2020
Publish dateJun 27, 2020 (structure data deposition date)
AuthorsAl-Khami, A.A. / Youssef, S. / Abdiche, Y. / Nguyen, H. / Chou, J. / Kimberlin, C.R. / Chin, S.M. / Kamperschroer, C. / Jessen, B. / Kern, B. ...Al-Khami, A.A. / Youssef, S. / Abdiche, Y. / Nguyen, H. / Chou, J. / Kimberlin, C.R. / Chin, S.M. / Kamperschroer, C. / Jessen, B. / Kern, B. / Budimir, N. / Dillon, C.P. / Xu, A. / Clark, J.D. / Kraynov, E. / Rajpal, A. / Lin, J.C. / Salek-Ardakani, S.
External linksMol. Cancer Ther. / PubMed:32847983
MethodsX-ray diffraction
Resolution2.59 Å
Structure data

PDB-6xkr:
Structure of Sasanlimab Fab in complex with PD-1
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN/IMMUNE SYSTEM / anti-PD-1 / Fab / Complex / Immuno-Oncology / ANTITUMOR PROTEIN / ANTITUMOR PROTEIN-IMMUNE SYSTEM complex

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