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Structure paper

Titlegamma-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics.
Journal, issue, pagesEmbo J., Vol. 39, Page e104247-e104247, Year 2020
Publish dateMay 8, 2020 (structure data deposition date)
AuthorsSteiner, A. / Schlepckow, K. / Brunner, B. / Steiner, H. / Haass, C. / Hagn, F.
External linksEmbo J. / PubMed:32830336
MethodsNMR (solution)
Structure data

PDB-6z0g:
Structure of TREM2 transmembrane helix in DPC micelles
Method: SOLUTION NMR

PDB-6z0h:
Structure of TREM2 transmembrane helix K186A variant in DPC micelles
Method: SOLUTION NMR

PDB-6z0i:
Structure of the TREM2 transmembrane helix in complex with DAP12 in DPC micelles
Method: SOLUTION NMR

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / neurodegeneration / proteolysis

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