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TitleAffinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis.
Journal, issue, pagesJ. Exp. Med., Vol. 217, Year 2020
Publish dateMay 13, 2020 (structure data deposition date)
AuthorsFichtner, M.L. / Vieni, C. / Redler, R.L. / Kolich, L. / Jiang, R. / Takata, K. / Stathopoulos, P. / Suarez, P.A. / Nowak, R.J. / Burden, S.J. ...Fichtner, M.L. / Vieni, C. / Redler, R.L. / Kolich, L. / Jiang, R. / Takata, K. / Stathopoulos, P. / Suarez, P.A. / Nowak, R.J. / Burden, S.J. / Ekiert, D.C. / O'Connor, K.C.
External linksJ. Exp. Med. / PubMed:32820331
MethodsX-ray diffraction
Resolution1.75 - 1.8 Å
Structure data

PDB-6wyr:
Crystal structure of anti-Muscle Specific Kinase (MuSK) Fab, MuSK1A
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6wyt:
Crystal structure of anti-Muscle Specific Kinase (MuSK) Fab, MuSK1B
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Human Fab / anti-MuSK

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