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Structure paper

TitleMn2+Directly Activates cGAS and Structural Analysis Suggests Mn2+Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.
Journal, issue, pagesCell Rep, Vol. 32, Page 108053-108053, Year 2020
Publish dateApr 7, 2020 (structure data deposition date)
AuthorsZhao, Z. / Ma, Z. / Wang, B. / Guan, Y. / Su, X.D. / Jiang, Z.
External linksCell Rep / PubMed:32814054
MethodsX-ray diffraction
Resolution2.13 - 3.091 Å
Structure data

PDB-7buj:
mcGAS bound with pppGpG
Method: X-RAY DIFFRACTION / Resolution: 2.13 Å

PDB-7bum:
mcGAS bound with pGpA
Method: X-RAY DIFFRACTION / Resolution: 3.047 Å

PDB-7buq:
mcGAS bound with 23-cGAMP
Method: X-RAY DIFFRACTION / Resolution: 3.091 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MN:
Unknown entry

ChemComp-5GP:
GUANOSINE-5'-MONOPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-1SY:
cGAMP

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / mcGAS / DNA-bingding / activator / inverted-orientation / cGAS / metal-ion binding protein

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