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TitlePeptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens.
Journal, issue, pagesJ. Med. Chem., Vol. 63, Page 9590-9602, Year 2020
Publish dateAug 11, 2020 (structure data deposition date)
AuthorsMardirossian, M. / Sola, R. / Beckert, B. / Valencic, E. / Collis, D.W.P. / Borisek, J. / Armas, F. / Di Stasi, A. / Buchmann, J. / Syroegin, E.A. ...Mardirossian, M. / Sola, R. / Beckert, B. / Valencic, E. / Collis, D.W.P. / Borisek, J. / Armas, F. / Di Stasi, A. / Buchmann, J. / Syroegin, E.A. / Polikanov, Y.S. / Magistrato, A. / Hilpert, K. / Wilson, D.N. / Scocchi, M.
External linksJ. Med. Chem. / PubMed:32787108
MethodsX-ray diffraction
Resolution3 - 3.05 Å
Structure data

PDB-7jql:
Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-7jqm:
Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

Source
  • thermus thermophilus hb8 (bacteria)
  • escherichia coli (E. coli)
  • escherichia virus t4
  • bos taurus (domestic cattle)
KeywordsRIBOSOME / Bactenecin 7; antibiotic; 70S ribosome; X-ray structure; inhibition of translation; peptidyl transferase center; nascent peptide exit tunnel

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