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Title | ANT2681: SAR Studies Leading to the Identification of a Metallo-beta-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-ProducingEnterobacteriaceae. |
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Journal, issue, pages | Acs Infect Dis., Vol. 6, Page 2419-2430, Year 2020 |
Publish date | Jun 19, 2020 (structure data deposition date) |
Authors | Davies, D.T. / Leiris, S. / Sprynski, N. / Castandet, J. / Lozano, C. / Bousquet, J. / Zalacain, M. / Vasa, S. / Dasari, P.K. / Pattipati, R. ...Davies, D.T. / Leiris, S. / Sprynski, N. / Castandet, J. / Lozano, C. / Bousquet, J. / Zalacain, M. / Vasa, S. / Dasari, P.K. / Pattipati, R. / Vempala, N. / Gujjewar, S. / Godi, S. / Jallala, R. / Sathyap, R.R. / Darshanoju, N.A. / Ravu, V.R. / Juventhala, R.R. / Pottabathini, N. / Sharma, S. / Pothukanuri, S. / Holden, K. / Warn, P. / Marcoccia, F. / Benvenuti, M. / Pozzi, C. / Mangani, S. / Docquier, J.D. / Lemonnier, M. / Everett, M. |
External links | Acs Infect Dis. / PubMed:32786279 |
Methods | X-ray diffraction |
Resolution | 1.65 Å |
Structure data | PDB-6zgm: |
Chemicals | ChemComp-ZN: ChemComp-ACT: ChemComp-QKK: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Metallo-beta-lactamase / triazole-thione inhibitor / antibiotic resistance / carbapenem-hydrolyzing beta-lactamase |