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TitleAn Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
Journal, issue, pagesJ Immunol., Vol. 205, Page 1678-1694, Year 2020
Publish dateApr 23, 2020 (structure data deposition date)
AuthorsZarantonello, A. / Presumey, J. / Simoni, L. / Yalcin, E. / Fox, R. / Hansen, A. / Olesen, H.G. / Thiel, S. / Johnson, M.B. / Stevens, B. ...Zarantonello, A. / Presumey, J. / Simoni, L. / Yalcin, E. / Fox, R. / Hansen, A. / Olesen, H.G. / Thiel, S. / Johnson, M.B. / Stevens, B. / Laursen, N.S. / Carroll, M.C. / Andersen, G.R.
External linksJ Immunol. / PubMed:32769120
MethodsX-ray diffraction
Resolution3.3 Å
Structure data

PDB-6ysq:
The hC4Nb8 complement inhibitory nanobody in complex with C4b
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Source
  • escherichia coli (E. coli)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Nanobody / inhibitor / complement C4b

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