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TitleAn orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Journal, issue, pagesEur. J. Med. Chem., Vol. 205, Page 112501-112501, Year 2020
Publish dateAug 7, 2019 (structure data deposition date)
AuthorsKim, J. / Hwang, H. / Yoon, H. / Lee, J.E. / Oh, J.M. / An, H. / Ji, H.D. / Lee, S. / Cha, E. / Ma, M.J. ...Kim, J. / Hwang, H. / Yoon, H. / Lee, J.E. / Oh, J.M. / An, H. / Ji, H.D. / Lee, S. / Cha, E. / Ma, M.J. / Kim, D.S. / Lee, S.J. / Kadayat, T.M. / Song, J. / Lee, S.W. / Jeon, J.H. / Park, K.G. / Lee, I.K. / Jeon, Y.H. / Chin, J. / Cho, S.J.
External linksEur. J. Med. Chem. / PubMed:32758860
MethodsX-ray diffraction
Resolution2.804 Å
Structure data

PDB-6knr:
Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699
Method: X-RAY DIFFRACTION / Resolution: 2.804 Å

Chemicals

ChemComp-DL9:
(E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Estrogen-related receptor gamma

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