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-Structure paper
Title | Discovery of 2,6-difluorobenzyl ether series of phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfones as surprisingly potent, selective and orally bioavailable ROR gamma t inverse agonists. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 30, Page 127441-127441, Year 2020 |
Publish date | Jul 20, 2020 (structure data deposition date) |
![]() | Duan, J.J. / Jiang, B. / Lu, Z. / Stachura, S. / Weigelt, C.A. / Sack, J.S. / Khan, J. / Ruzanov, M. / Wu, D.R. / Yarde, M. ...Duan, J.J. / Jiang, B. / Lu, Z. / Stachura, S. / Weigelt, C.A. / Sack, J.S. / Khan, J. / Ruzanov, M. / Wu, D.R. / Yarde, M. / Shen, D.R. / Zhao, Q. / Salter-Cid, L.M. / Carter, P.H. / Murali Dhar, T.G. |
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Methods | X-ray diffraction |
Resolution | 2.367 Å |
Structure data | ![]() PDB-7jh2: |
Chemicals | ![]() ChemComp-VBG: ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSCRIPTION/AGONIST / RORGT / NUCLEAR HORMONE RECEPTOR / LIGAND-BINDING DOMAIN / INVERSE AGONIST / TRANSCRIPTION-AGONIST complex |