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TitleCrystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design.
Journal, issue, pagesSignal Transduct Target Ther, Vol. 5, Page 131-131, Year 2020
Publish dateMay 7, 2020 (structure data deposition date)
AuthorsLin, S. / Chen, H. / Ye, F. / Chen, Z. / Yang, F. / Zheng, Y. / Cao, Y. / Qiao, J. / Yang, S. / Lu, G.
External linksSignal Transduct Target Ther / PubMed:32728018
MethodsX-ray diffraction
Resolution2.5 - 2.799 Å
Structure data

PDB-7c2i:
Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (with additional SAM during crystallization)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-7c2j:
Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (without additional SAM during crystallization)
Method: X-RAY DIFFRACTION / Resolution: 2.799 Å

Chemicals

ChemComp-SAM:
S-ADENOSYLMETHIONINE

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / 2'-O-Methylase

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